Anna is so smart. :) However, it's also the author's job to know which genre you're writing. Otherwise, even if you do sell the book, too many readers will not be happy. Sales will not be happy, neither will marketing or publicity. And many editors aren't as open minded as Anna. They want to be able to take your book to marketing and sales and say, this book will sell because it's like Ms. New York Times best selling author's book--only sassier. Of course there are always exceptions--but it's hard enough to sell a book, why buck the odds?